Report

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

See allHide authors and affiliations

Science  12 Jun 2009:
Vol. 324, Issue 5933, pp. 1457-1461
DOI: 10.1126/science.1171362

Article Information

vol. 324 no. 5933 1457-1461

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 26, 2009
  • Accepted for publication April 23, 2009
  • .

Article Versions

Author Information

  1. Kenneth P. Olive1,
  2. Michael A. Jacobetz1,*,
  3. Christian J. Davidson2,*,
  4. Aarthi Gopinathan1,2,*,
  5. Dominick McIntyre1,
  6. Davina Honess1,
  7. Basetti Madhu1,
  8. Mae A. Goldgraben1,
  9. Meredith E. Caldwell1,
  10. David Allard1,
  11. Kristopher K. Frese1,
  12. Gina DeNicola1,2,
  13. Christine Feig1,
  14. Chelsea Combs2,
  15. Stephen P. Winter1,
  16. Heather Ireland-Zecchini1,
  17. Stefanie Reichelt1,
  18. William J. Howat1,
  19. Alex Chang3,
  20. Mousumi Dhara3,
  21. Lifu Wang2,4,
  22. Felix Rückert5,
  23. Robert Grützmann5,
  24. Christian Pilarsky5,
  25. Kamel Izeradjene6,
  26. Sunil R. Hingorani6,
  27. Pearl Huang7,
  28. Susan E. Davies8,
  29. William Plunkett9,
  30. Merrill Egorin10,
  31. Ralph H. Hruban3,
  32. Nigel Whitebread11,
  33. Karen McGovern11,
  34. Julian Adams11,
  35. Christine Iacobuzio-Donahue3,
  36. John Griffiths1 and
  37. David A. Tuveson1,
  1. 1Cancer Research UK, Cambridge Research Institute, The Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, UK.
  2. 2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3Departments of Oncology and Pathology, The Sol Goldman Pancreatic Cancer Research Center, Sidney Cancer Center and Johns Hopkins University, Baltimore, MD 21287, USA.
  4. 4Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
  5. 5Department of Surgery, University Hospital Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
  6. 6Clinical Research and Public Health Sciences Division, Fred Hutchinson Cancer Research Center (FHCRC), and University of Washington, Seattle, WA 98109, USA.
  7. 7Oncology Franchise, Merck and Company, North Wales, PA 19454, USA.
  8. 8Department of Histopathology, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service (NHS) Foundation Trust, Cambridge CB2 2QQ, UK.
  9. 9M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.
  10. 10Division of Hematology and Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
  11. 11Infinity Pharmaceuticals, Cambridge, MA 01239, USA.
  1. To whom correspondence should be addressed. E-mail: david.tuveson{at}cancer.org.uk

Altmetric

Article usage

Article usage: May 2009 to June 2020

AbstractFullPdf
May 200912740716
Jun 2009306113582651
Jul 2009635776926
Aug 2009300467474
Sep 2009290517497
Oct 2009231375388
Nov 2009317433442
Dec 2009152257263
Jan 2010206358394
Feb 2010155292268
Mar 2010183326309
Apr 2010184290293
May 2010192284245
Jun 2010130255191
Jul 2010181245234
Aug 2010322126205
Sep 201048699269
Oct 2010406127253
Nov 2010676139277
Dec 201050567147
Jan 2011669113205
Feb 2011511123180
Mar 2011619123247
Apr 201151676189
May 201144571147
Jun 201148787177
Jul 201143886165
Aug 201137685140
Sep 201146286162
Oct 201158297210
Nov 2011574107207
Dec 201146274177
Jan 201243577165
Feb 201258592200
Mar 2012596102164
Apr 2012470106136
May 2012392198153
Jun 2012258135128
Jul 2012229116108
Aug 201229010394
Sep 2012280127131
Oct 2012725151130
Nov 201242111597
Dec 20123078981
Jan 2013344150146
Feb 2013281158123
Mar 2013324117110
Apr 2013385144127
May 2013362160148
Jun 201323310399
Jul 2013236118109
Aug 2013283130138
Sep 2013330124151
Oct 2013461130141
Nov 2013467133157
Dec 201334496115
Jan 2014370119127
Feb 2014319134118
Mar 2014382165107
Apr 2014363139108
May 2014340115118
Jun 2014292126135
Jul 2014299137126
Aug 201418611297
Sep 2014268145116
Oct 2014502127115
Nov 2014355144129
Dec 201425012898
Jan 2015269129117
Feb 20152288691
Mar 2015263130109
Apr 201526112394
May 201524411597
Jun 201519311198
Jul 20152288978
Aug 20151947776
Sep 20153009580
Oct 201529812693
Nov 2015308112110
Dec 20153119675
Jan 20162595244
Feb 20163166995
Mar 20163593488
Apr 20163084492
May 201635357103
Jun 20163545294
Jul 201640558103
Aug 201643162105
Sep 20164085782
Oct 20163806198
Nov 201649864111
Dec 20163445482
Jan 20174435986
Feb 20174136999
Mar 201743571122
Apr 201742683109
May 20173856296
Jun 20172974471
Jul 20172213564
Aug 20172966266
Sep 20172686982
Oct 20173085776
Nov 20173186298
Dec 20172663967
Jan 20182795268
Feb 20183125885
Mar 20183596796
Apr 20182665075
May 20182363166
Jun 20181983572
Jul 20181696180
Aug 20189010497
Sep 20181379592
Oct 2018108130102
Nov 2018173159112
Dec 20181569588
Jan 201915311981
Feb 201913812656
Mar 201918019969
Apr 201912720570
May 201914423779
Jun 201911018087
Jul 201915019983
Aug 201919917959
Sep 201912713841
Oct 201910822465
Nov 201914415059
Dec 201914410571
Jan 202017111144
Feb 202012211151
Mar 202015410681
Apr 202022111673
May 20201207848
Jun 20201864

Stay Connected to Science