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Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

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Science  17 Jul 2009:
Vol. 325, Issue 5938, pp. 328-332
DOI: 10.1126/science.1173155

Article Information

vol. 325 no. 5938 328-332

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History: 
  • Received for publication March 6, 2009
  • Accepted for publication May 18, 2009
  • .

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Author Information

  1. Samir K. Maji1,*,
  2. Marilyn H. Perrin2,
  3. Michael R. Sawaya3,
  4. Sebastian Jessberger4,
  5. Krishna Vadodaria4,
  6. Robert A. Rissman5,
  7. Praful S. Singru6,
  8. K. Peter R. Nilsson7,
  9. Rozalyn Simon7,
  10. David Schubert8,
  11. David Eisenberg3,
  12. Jean Rivier2,
  13. Paul Sawchenko2,
  14. Wylie Vale2 and
  15. Roland Riek1,9,
  1. 1Laboratory of Physical Chemistry, Eidgenössische Technische Hochschule (ETH) Zürich, Wolfgang-Paulistrasse 10, CH-8093 Zürich, Switzerland.
  2. 2Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  3. 3Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Box 951570, University of California, Los Angeles, CA 90095, USA.
  4. 4Institute of Cell Biology, Department of Biology, ETH Zürich, 8093 Zürich, Switzerland.
  5. 5Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA.
  6. 6Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, USA.
  7. 7Department of Chemistry, IFM, Linköping University, SE-581 83 Linköping, Sweden.
  8. 8Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  9. 9Structural Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  1. To whom correspondence should be addressed. E-mail: roland.riek{at}phys.chem.ethz.ch

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