Technical Comments

Comment on “Remeasuring the Double Helix”

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Science  31 Jul 2009:
Vol. 325, Issue 5940, pp. 538
DOI: 10.1126/science.1168786


Mathew-Fenn et al. (Reports, 17 October 2008, p. 446) reported unexpected distance fluctuations in short end-labeled DNA constructs and interpreted them as evidence for cooperative DNA stretching modes. We show that when accounting for a subtle linker leverage effect, their data can be understood within standard noncooperative DNA elasticity.

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