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Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima

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Science  18 Sep 2009:
Vol. 325, Issue 5947, pp. 1544-1549
DOI: 10.1126/science.1174671

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With the advent of systems-wide technologies and the development of analytical methods, data produced by analyzing individual or small groups of molecular components can be integrated to reassemble whole biological systems. Zhang et al. (p. 1544) have undertaken a major technological challenge: to integrate biochemical data with experimentally determined or predicted three-dimensional structures of all proteins involved in the central metabolism of a bacterial cell. This integration of large-scale data sets provides evolutionary and functional insights and furthers our understanding of the molecular assembly of complex biological networks.

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