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Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
- Jihye Yun1,
- Carlo Rago1,
- Ian Cheong1,
- Ray Pagliarini1,*,
- Philipp Angenendt1,
- Harith Rajagopalan1,†,
- Kerstin Schmidt1,
- James K. V. Willson2,
- Sandy Markowitz3,
- Shibin Zhou1,
- Luis A. Diaz Jr1,
- Victor E. Velculescu1,
- Christoph Lengauer1,‡,
- Kenneth W. Kinzler1,
- Bert Vogelstein1,§,
- Nickolas Papadopoulos1
- 1The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.
- 2Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
- 3Department of Medicine and Ireland Cancer Center, Case Western Reserve University and Case Medical Center of University Hospitals of Cleveland and Howard Hughes Medical Institute, Cleveland, OH 44106, USA.
- ↵§To whom correspondence should be addressed. E-mail: vogelbe{at}jhmi.edu
See allHide authors and affiliations
Science 18 Sep 2009:
Vol. 325, Issue 5947, pp. 1555-1559
DOI: 10.1126/science.1174229
Vol. 325, Issue 5947, pp. 1555-1559
DOI: 10.1126/science.1174229
Jihye Yun
Carlo Rago
Ian Cheong
Ray Pagliarini
Philipp Angenendt
Harith Rajagopalan
Kerstin Schmidt
James K. V. Willson
Sandy Markowitz
Shibin Zhou
Luis A. Diaz Jr
Victor E. Velculescu
Christoph Lengauer
Kenneth W. Kinzler
Bert Vogelstein
Nickolas Papadopoulos
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