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A Spindle Assembly Checkpoint Protein Functions in Prophase I Arrest and Prometaphase Progression

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Science  13 Nov 2009:
Vol. 326, Issue 5955, pp. 991-994
DOI: 10.1126/science.1175326

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BubR1 Broadens Its Remit

During mitosis in mammalian somatic cells, BubR1 is indispensable for spindle assembly checkpoint signaling and for establishing contacts between chromosomes and spindle microtubules. Homer et al. (p. 991) found that in mouse oocytes during meiosis I, BubR1 was not only required to sustain prophase I arrest but also for promoting the completion of meiosis I. Both effects converge on the Cdh1 coactivator of the multimeric ubiquitin ligase, known as the anaphase-promoting complex, and both functions are required for the production of fertilizable eggs.

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