Evolution of MRSA During Hospital Transmission and Intercontinental Spread

Simon R. Harris; Edward J. Feil; Matthew T. G. Holden; Michael A. Quail; Emma K. Nickerson; Narisara Chantratita; Susana Gardete; Ana Tavares; Nick Day; Jodi A. Lindsay; Jonathan D. Edgeworth; Hermínia de Lencastre; Julian Parkhill; Sharon J. Peacock; Stephen D. Bentley

doi:10.1126/science.1182395

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Evolution of MRSA During Hospital Transmission and Intercontinental Spread

Simon R. Harris¹,*,
Edward J. Feil²,*,
Matthew T. G. Holden¹,
Michael A. Quail¹,
Emma K. Nickerson³,⁴,
Narisara Chantratita³,
Susana Gardete⁵,⁶,
Ana Tavares⁵,
Nick Day³,⁷,
Jodi A. Lindsay⁸,
Jonathan D. Edgeworth⁹,¹⁰,
Hermínia de Lencastre⁵,⁶,
Julian Parkhill¹,
Sharon J. Peacock³,⁴,
Stephen D. Bentley¹,†

¹The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK.
²Department of Biology and Biochemistry, University of Bath, South Building, Claverton Down, Bath BA2 7AY, UK.
³Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
⁴Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.
⁵Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal.
⁶Laboratory of Microbiology, The Rockefeller University, New York, NY 10065, USA.
⁷Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK.
⁸Centre for Infection, Department of Cellular and Molecular Medicine, St. George’s, University of London, Cranmer Terrace, London SW17 0RE, UK.
⁹Department of Infectious Diseases, King’s College London, Guy’s, King’s, and St. Thomas’ Medical School, Guy’s Hospital, London SE1 9RT, UK.
¹⁰Directorate of Infection, Guy’s and St. Thomas’ National Health Service Foundation Trust, London SE1 7EH, UK.

↵†To whom correspondence should be addressed. E-mail: sdb{at}sanger.ac.uk

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Science 22 Jan 2010:
Vol. 327, Issue 5964, pp. 469-474
DOI: 10.1126/science.1182395

Simon R. Harris

1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK.

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Edward J. Feil

2Department of Biology and Biochemistry, University of Bath, South Building, Claverton Down, Bath BA2 7AY, UK.

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Matthew T. G. Holden

1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK.

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Michael A. Quail

1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK.

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Emma K. Nickerson

3Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

4Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.

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Narisara Chantratita

3Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

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Susana Gardete

5Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal.

6Laboratory of Microbiology, The Rockefeller University, New York, NY 10065, USA.

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Ana Tavares

5Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal.

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Nick Day

3Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

7Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK.

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Jodi A. Lindsay

8Centre for Infection, Department of Cellular and Molecular Medicine, St. George’s, University of London, Cranmer Terrace, London SW17 0RE, UK.

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Jonathan D. Edgeworth

9Department of Infectious Diseases, King’s College London, Guy’s, King’s, and St. Thomas’ Medical School, Guy’s Hospital, London SE1 9RT, UK.

10Directorate of Infection, Guy’s and St. Thomas’ National Health Service Foundation Trust, London SE1 7EH, UK.

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Hermínia de Lencastre

5Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal.

6Laboratory of Microbiology, The Rockefeller University, New York, NY 10065, USA.

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Julian Parkhill

1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK.

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Sharon J. Peacock

3Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

4Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.

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Stephen D. Bentley

1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 15A, UK.

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For correspondence: sdb@sanger.ac.uk

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