Research Article

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

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Science  05 Mar 2010:
Vol. 327, Issue 5970, pp. 1223-1228
DOI: 10.1126/science.1182228

Article Information

vol. 327 no. 5970 1223-1228

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 21, 2009
  • Accepted for publication January 6, 2010
  • .

Author Information

  1. Jun Hee Lee1,
  2. Andrei V. Budanov1,
  3. Eek Joong Park1,
  4. Ryan Birse2,
  5. Teddy E. Kim3,
  6. Guy A. Perkins4,
  7. Karen Ocorr2,
  8. Mark H. Ellisman4,
  9. Rolf Bodmer2,
  10. Ethan Bier3,* and
  11. Michael Karin1,*
  1. 1Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093–0723, USA.
  2. 2Development and Aging Program, Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
  3. 3Section of Cell and Developmental Biology, UCSD, La Jolla, CA 92093–0349, USA.
  4. 4National Center for Microscopy and Imaging Research and Department of Neurosciences, UCSD, La Jolla, CA 92093–0608, USA.
  1. *To whom correspondence should be addressed. E-mail: ebier{at}ucsd.edu (E.B.); karinoffice{at}ucsd.edu (M.K.)

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