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Transnuclear Mice with Predefined T Cell Receptor Specificities Against Toxoplasma gondii Obtained via SCNT

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Science  09 Apr 2010:
Vol. 328, Issue 5975, pp. 243-248
DOI: 10.1126/science.1178590

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Speedy TCR Transgenic Mouse Manufacture

T cell receptor (TCR) transgenic mice are one of the most useful and ubiquitous tools of the immunologist. This is because the majority of T cells that develop in these mice express T cell receptors with known antigen specificity, and thus the mice can be used to study antigen-specific immune responses. The downside of TCR transgenic mice is that they can be difficult and time-consuming to generate and the antigen specificities of their T cells are often not physiologically relevant. Kirak et al. (p. 243) now describe the use of somatic cell nuclear transfer to create TCR transgenic mice with specificity for antigens known to be important in the immune response against the parasite Toxoplasma gondii. This method generates mice with greater ease and speed than conventional TCR transgenic mice and can be applied to generate mice with T cells specific to antigens from a variety of infectious diseases.

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