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Response to Comment on “Homeostatic Sleep Pressure and Responses to Sustained Attention in the Suprachiasmatic Area”

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Science  16 Apr 2010:
Vol. 328, Issue 5976, pp. 309
DOI: 10.1126/science.1177949


Astafiev et al. question whether the blood oxygen level–dependent (BOLD) response that we reported in the brainstem was located in the locus coeruleus (LC). Using high-resolution T1-turbo spin echo images (T1-TSE) acquired in an independent group of subjects, we show that the reported task-related BOLD response in the brainstem is actually compatible with the anatomical location of the LC.

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