Research Article

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

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Science  23 Jul 2010:
Vol. 329, Issue 5990, pp. 413-417
DOI: 10.1126/science.1190897

Article Information

vol. 329 no. 5990 413-417

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History: 
  • Received for publication April 14, 2010
  • Accepted for publication June 11, 2010
  • .

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Author Information

  1. Volker Busskamp1,2,*,
  2. Jens Duebel1,*,
  3. David Balya1,*,
  4. Mathias Fradot3,4,5,
  5. Tim James Viney1,
  6. Sandra Siegert1,
  7. Anna C. Groner2,6,
  8. Erik Cabuy1,
  9. Valérie Forster3,4,5,
  10. Mathias Seeliger7,
  11. Martin Biel8,
  12. Peter Humphries9,
  13. Michel Paques3,4,5,10,11,
  14. Saddek Mohand-Said3,4,5,10,
  15. Didier Trono2,6,
  16. Karl Deisseroth12,
  17. José A. Sahel3,4,5,10,11,
  18. Serge Picaud3,4,5,11 and
  19. Botond Roska1,
  1. 1Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
  2. 2National Centre of Competence in Research Frontiers in Genetics Program, Geneva 1211, Switzerland.
  3. 3Inserm, UMR_S968, Institut de la Vision, Paris, France.
  4. 4Université Pierre et Marie Curie Paris 06, UMR_S968, Institut de la Vision, Paris F-75012, France.
  5. 5CNRS, UMR_7210, Paris F-75012, France.
  6. 6School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  7. 7Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Department of Ophthalmology II, Eberhard-Karls University, Tübingen, Germany.
  8. 8Center for Integrated Protein Science Munich and Department of Pharmacy, Ludwig-Maximilians-Universität München, Munich, Germany.
  9. 9Smurfit Institute of Genetics, Trinity College, Dublin, Ireland.
  10. 10Centre d’Investigation Clinique 503, Inserm-Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Paris, France.
  11. 11Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
  12. 12Department of Bioengineering and Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
  1. To whom correspondence should be addressed. E-mail: botond.roska{at}fmi.ch
  1. * These authors contributed equally to this work.

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