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Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes

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Science  23 Jul 2010:
Vol. 329, Issue 5990, pp. 444-448
DOI: 10.1126/science.1190485

Article Information

vol. 329 no. 5990 444-448

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Print ISSN: 
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History: 
  • Received for publication April 5, 2010
  • Accepted for publication June 3, 2010

Author Information

  1. Hao Wu1,*,
  2. Volkan Coskun2,
  3. Jifang Tao2,
  4. Wei Xie3,
  5. Weihong Ge1,
  6. Kazuaki Yoshikawa4,
  7. En Li5,
  8. Yi Zhang6 and
  9. Yi Eve Sun1,2,*
  1. 1Department of Molecular and Medical Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
  2. 2Department of Psychiatry and Biobehavioral Sciences, Intellectual Development and Disabilities Research Center at Semel Institute for Neuroscience, UCLA, Los Angeles, CA 90095, USA.
  3. 3Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA.
  4. 4Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka, 565-0871, Japan.
  5. 5Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  6. 6Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  1. *To whom correspondence should be addressed. E-mail: ysun{at}mednet.ucla.edu (Y.E.S.); haowu7{at}gmail.com (H.W.)

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