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Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I

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Science  23 Jul 2010:
Vol. 329, Issue 5990, pp. 448-451
DOI: 10.1126/science.1191046

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Complex I Under Scrutiny

Mitochondrial complex I is a large macromolecular membrane complex that couples electron transfer to proton pumping across the mitochondrial membrane and helps to drive adenosine 5′-triphosphate synthesis. Hunte et al. (p. 448, published online 1 July) now describe the structure of complex 1 from the aerobic yeast, Yarrowia lipolytica. The sites involved in redox chemistry are distant from those that pump protons, and the structure suggests that a 60-angstrom-long helix is involved in transducing energy to the proton-pumping elements.