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Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

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Science  13 Aug 2010:
Vol. 329, Issue 5993, pp. 841-845
DOI: 10.1126/science.1193032

Article Information

vol. 329 no. 5993 841-845

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History: 
  • Received for publication June 1, 2010
  • Accepted for publication July 1, 2010
  • .

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Author Information

  1. Giulio Genovese1,2,*,
  2. David J. Friedman1,3,*,
  3. Michael D. Ross4,
  4. Laurence Lecordier5,
  5. Pierrick Uzureau5,
  6. Barry I. Freedman6,
  7. Donald W. Bowden7,8,
  8. Carl D. Langefeld8,9,
  9. Taras K. Oleksyk10,
  10. Andrea L. Uscinski Knob4,
  11. Andrea J. Bernhardy1,
  12. Pamela J. Hicks7,8,
  13. George W. Nelson11,
  14. Benoit Vanhollebeke5,
  15. Cheryl A. Winkler12,
  16. Jeffrey B. Kopp11,
  17. Etienne Pays5,,
  18. Martin R. Pollak1,13,
  1. 1Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
  2. 2Department of Mathematics, Dartmouth College, Hanover, NH 03755, USA.
  3. 3Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
  4. 4Renal Division, Department of Medicine, Brigham and Women’s Hospital (BWH), Boston, MA 02215, USA.
  5. 5Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles, B-6041 Gosselies, Belgium.
  6. 6Department of Internal Medicine/Section on Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
  7. 7Department of Biochemistry and Center for Diabetes Research, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
  8. 8Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
  9. 9Department of Biostatistical Sciences, Center for Public Health Genomics and Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
  10. 10Department of Biology, University of Puerto Rico at Mayaguez, Mayaguez, Puerto Rico 00681.
  11. 11Kidney Disease Section, National Institute of Diabetes, Digestive, and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA.
  12. 12Laboratory of Genomic Diversity, SAIC-Frederick, Incorporated, National Cancer Institute–Frederick, Frederick, MD 21702, USA.
  13. 13Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  1. To whom correspondence should be addressed. E-mail: mpollak{at}bidmc.harvard.edu (M.R.P.); epays{at}ulb.ac.be (E.P.)
  1. * These authors contributed equally to this work.

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