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Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

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Science  13 Aug 2010:
Vol. 329, Issue 5993, pp. 856-861
DOI: 10.1126/science.1187659

Article Information

vol. 329 no. 5993 856-861

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History: 
  • Received for publication January 28, 2010
  • Accepted for publication May 4, 2010

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Author Information

  1. Xueling Wu1,*,
  2. Zhi-Yong Yang1,*,
  3. Yuxing Li1,*,
  4. Carl-Magnus Hogerkorp1,,
  5. William R. Schief4,
  6. Michael S. Seaman5,
  7. Tongqing Zhou1,
  8. Stephen D. Schmidt1,
  9. Lan Wu1,
  10. Ling Xu1,
  11. Nancy S. Longo1,
  12. Krisha McKee1,
  13. Sijy O’Dell1,
  14. Mark K. Louder1,
  15. Diane L. Wycuff1,
  16. Yu Feng1,,
  17. Martha Nason2,
  18. Nicole Doria-Rose3,
  19. Mark Connors3,
  20. Peter D. Kwong1,
  21. Mario Roederer1,
  22. Richard T. Wyatt1,,
  23. Gary J. Nabel1,§,
  24. John R. Mascola1,§
  1. 1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  3. 3Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  4. 4Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  5. 5Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
  1. §To whom correspondence should be addressed. E-mail: gnabel{at}nih.gov (G.J.N.); jmascola{at}nih.gov (J.R.M.)
  1. * These authors contributed equally to this work.

  • Present address: Department of Molecular Genetics, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark.

  • Present address: Department of Immunology and Microbial Science, and IAVI Center for Neutralizing Antibody at TSRI, Scripps Research Institute, La Jolla, CA 92037, USA.

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