Report

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

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Science  20 Aug 2010:
Vol. 329, Issue 5994, pp. 959-964
DOI: 10.1126/science.1190287

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  • mTOR Activation: Does a Body Good?

    We were interested to read the Report by N. Li and colleagues who use animal models to demonstrate that the rapid antidepressant effects of ketamine, at the biochemical, histological, and behavioral levels are dependent on activation of mTOR ("mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists," 20 August 2010, p. 959). Based on these findings the authors suggest that mTOR activatio...

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    Competing Interests: None declared.