Research Article

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

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Science  03 Sep 2010:
Vol. 329, Issue 5996, pp. 1175-1180
DOI: 10.1126/science.1193225

Article Information

vol. 329 no. 5996 1175-1180

PubMed: 
Print ISSN: 
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History: 
  • Received for publication June 3, 2010
  • Accepted for publication June 30, 2010
  • .

Author Information

  1. Matthias Rottmann1,2,*,
  2. Case McNamara3,*,
  3. Bryan K. S. Yeung4,*,
  4. Marcus C. S. Lee5,
  5. Bin Zou4,
  6. Bruce Russell6,7,
  7. Patrick Seitz1,2,
  8. David M. Plouffe3,
  9. Neekesh V. Dharia8,
  10. Jocelyn Tan4,
  11. Steven B. Cohen3,
  12. Kathryn R. Spencer8,
  13. Gonzalo E. González-Páez8,
  14. Suresh B. Lakshminarayana4,
  15. Anne Goh4,
  16. Rossarin Suwanarusk6,
  17. Timothy Jegla9,
  18. Esther K. Schmitt10,
  19. Hans-Peter Beck1,2,
  20. Reto Brun1,2,
  21. Francois Nosten11,12,13,
  22. Laurent Renia6,
  23. Veronique Dartois4,
  24. Thomas H. Keller4,
  25. David A. Fidock5,14,
  26. Elizabeth A. Winzeler3,8, and
  27. Thierry T. Diagana4,*
  1. 1Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH-4002 Basel, Switzerland.
  2. 2University of Basel, CH-4003 Basel, Switzerland.
  3. 3Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
  4. 4Novartis Institute for Tropical Diseases, 138670 Singapore.
  5. 5Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
  6. 6Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Biopolis, 138648, Singapore.
  7. 7Department of Microbiology, National University of Singapore, 117597, Singapore.
  8. 8Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  9. 9Department of Biology and Huck Institute of Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
  10. 10Natural Products Unit, Novartis Pharma AG, CH-4002 Basel, Switzerland.
  11. 11Shoklo Malaria Research Unit, Mae Sot, Tak 63110, Thailand.
  12. 12Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  13. 13Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7LJ, UK.
  14. 14Department of Medicine (Division of Infectious Diseases), Columbia University Medical Center, New York, NY 10032, USA.
  1. To whom correspondence should be addressed. E-mail: winzeler{at}scripps.edu (E.A.W.); thierry.diagana{at}novartis.com (T.T.D.)
  1. * These authors contributed equally to this work.

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