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Science  03 Sep 2010:
Vol. 329, Issue 5996, pp. 1219
DOI: 10.1126/science.329.5996.1219-a

Automated ChromatographY

The Octave Chromatography System is an automated chromatography platform designed for preparative-scale purification of chemical and biological compounds. The system is able to continuously process racemates, cell lysates, cell culture supernatants, and other crude fractions to yield grams of highly purified antibodies, proteins, sugars, amino acids, fatty acids, and other large and small molecules in just hours. The compact, versatile, and affordable system brings the benefits of simulated moving bed chromatography to the laboratory benchtop. The Octave System carries eight column positions arranged in series and connected through a proprietary pneumatic valve array. The valve and pump configuration provides ultimate flexibility in programming chromatographic protocols via the intuitive software. All flow paths consist of metal-free biocompatible materials that are also compatible with common organic solvents and clean-in-place solutions. The Octave System is available in two configurations with maximum flow rates up to 10 and 100 milliliter/minute.

solid phase extraction

Strata-X-A polymeric, high-capacity sorbent delivers maximum retention of anionic compounds, for anion/cation exchange separations. The base polymer of the new Strata-X-A is pH-stable and resists deconditioning, providing more flexibility during method development and reducing the potential for errors. Strata-X-A retains acidic analytes in three different ways: &-& and hydrophobic interactions coupled with a strong anion exchange mechanism. The strong ionic bond allows an aggressive organic wash, leaving the eluent free of interference. This sorbent is ideal for a wide variety of liquid chromatography and gas chromatography applications that involve acid analytes including environmental and forensic toxicology. Strata-X-A is offered in 1 mL, 3 mL, and 6 mL tubes for traditional cleanup, 96-well plates for high throughput extractions, and Giga Tubes (12 mL, 20 mL, and 60 mL) for large-volume applications.

Confocal MicroscopY

sample tracking

The 2D Barcode Reader is specially designed to provide advanced sample tracking functions on Microlab Star automated liquid handling workstation. The new reader has a compact footprint in a standard carrier size to minimize the required deck space. The reader's charge-coupled device camera records barcodes in less than 0.5 seconds from a wide range of sample formats including boxes of SBS tubes and biovials in 96-well format. Five labware positions are available on the device. The 2D barcode reader supports a variety of tubes from many manufacturers, in 24-, 48-, 96-, and 384-well configurations. The new reader is ideal for high throughput screening, sample archival, forensics, and work with single-nucleotide polymorphisms and blood samples.

PARP Pharmacodynamic Assay

The second generation Poly-ADP-ribose polymerase (PARP) in vivo pharmacodynamic assay accurately measures net poly-ADP-ribose (PAR) levels in cellular extracts and has been used to document differences in PAR levels in human tumor lysates from a variety of tissues, organs, and xenografts. The pharmacodynamic assay uses a validated sample processing regime and a chemiluminescent, sandwich enzyme-linked immunosorbent assay (ELISA) format, with pre-coated 96-stripwell plates. The assay reports PAR levels at high signal-to-noise ratio, with a sensitivity of two picograms/milliliter (pg/ml) and a linear dynamic range to 1000 pg/ml. The new tool provides evidence of drug action on molecular targets and generates baseline values that may be used to stratify patient response to therapy.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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