Report

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

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Science  05 Nov 2010:
Vol. 330, Issue 6005, pp. 831-835
DOI: 10.1126/science.1191175

Article Information

vol. 330 no. 6005 831-835

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History: 
  • Received for publication April 20, 2010
  • Accepted for publication August 27, 2010

Author Information

  1. Bret D. Wallace1,
  2. Hongwei Wang2,
  3. Kimberly T. Lane1,
  4. John E. Scott3,
  5. Jillian Orans1,
  6. Ja Seol Koo4,
  7. Madhukumar Venkatesh2,
  8. Christian Jobin4,
  9. Li-An Yeh3,
  10. Sridhar Mani2,
  11. Matthew R. Redinbo1,5,6
  1. 1Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
  2. 2Departments of Medicine, Oncology and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  3. 3Biomanufacturing Research Institute and Technology Enterprise (BRITE), North Carolina Central University, Durham, NC 27707, USA.
  4. 4Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
  5. 5Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
  6. 6Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
  1. *To whom correspondence should be addressed. E-mail: redinbo{at}unc.edu

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