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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

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Science  19 Nov 2010:
Vol. 330, Issue 6007, pp. 1091-1095
DOI: 10.1126/science.1197410

Article Information

vol. 330 no. 6007 1091-1095

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 6, 2010
  • Accepted for publication October 21, 2010
  • .

Author Information

  1. Ellen Y. T. Chien1,
  2. Wei Liu1,
  3. Qiang Zhao1,
  4. Vsevolod Katritch2,
  5. Gye Won Han1,
  6. Michael A. Hanson3,
  7. Lei Shi4,
  8. Amy Hauck Newman5,
  9. Jonathan A. Javitch6,
  10. Vadim Cherezov1 and
  11. Raymond C. Stevens1,*
  1. 1Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  2. 2Skaggs School of Pharmacy and Pharmaceutical Sciences, and San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA.
  3. 3Receptos, 10835 Road to the Cure, Suite 205, San Diego, CA 92121, USA.
  4. 4Department of Physiology and Biophysics and HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York, NY 10021, USA.
  5. 5Medicinal Chemistry Section, National Institute on Drug Abuse–Intramural Research Program, Baltimore, MD 21224, USA.
  6. 6Center for Molecular Recognition and Departments of Psychiatry and Pharmacology, Columbia University College of Physicians and Surgeons, 630 West 168th, New York, NY 10032, USA.
  1. *To whom correspondence should be addressed. E-mail: stevens{at}scripps.edu

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