03 December 2010
Vol 330, Issue 6009

About The Cover

Cover image expansion

COVER Autophagy, the process by which cells digest their own components, takes place in vesicles called autophagosomes (white membrane structures), the size of which are determined by the amount of a protein called Atg8. Basal amounts of Atg8 (small membraneassociated spheres) generate a small vesicle (middle left), whereas larger amounts cause formation of a full-fledged autophagosome (upper right). Autophagy provides fuel for cellular metabolism, the topic of the special section beginning on page 1337. Painting: David S. Goodsell; Scientifi c Design: Zhou Du and Daniel J. Klionsky