Research Article

The Genetic Landscape of the Childhood Cancer Medulloblastoma

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Science  28 Jan 2011:
Vol. 331, Issue 6016, pp. 435-439
DOI: 10.1126/science.1198056

Article Information

vol. 331 no. 6016 435-439

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History: 
  • Received for publication September 21, 2010
  • Accepted for publication December 8, 2010
  • .

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Author Information

  1. D. Williams Parsons1,2,*,
  2. Meng Li1,*,
  3. Xiaosong Zhang1,*,
  4. Siân Jones1,*,
  5. Rebecca J. Leary1,*,
  6. Jimmy Cheng-Ho Lin1,
  7. Simina M. Boca3,
  8. Hannah Carter4,
  9. Josue Samayoa4,
  10. Chetan Bettegowda1,5,
  11. Gary L. Gallia5,
  12. George I. Jallo5,
  13. Zev A. Binder5,
  14. Yuri Nikolsky6,
  15. James Hartigan7,
  16. Doug R. Smith7,
  17. Daniela S. Gerhard8,
  18. Daniel W. Fults9,
  19. Scott VandenBerg10,
  20. Mitchel S. Berger11,
  21. Suely Kazue Nagahashi Marie12,
  22. Sueli Mieko Oba Shinjo12,
  23. Carlos Clara13,
  24. Peter C. Phillips14,
  25. Jane E. Minturn14,
  26. Jaclyn A. Biegel14,
  27. Alexander R. Judkins16,,
  28. Adam C. Resnick15,
  29. Phillip B. Storm15,
  30. Tom Curran16,
  31. Yiping He17,
  32. B. Ahmed Rasheed17,
  33. Henry S. Friedman17,
  34. Stephen T. Keir17,
  35. Roger McLendon17,
  36. Paul A. Northcott18,
  37. Michael D. Taylor18,
  38. Peter C. Burger19,
  39. Gregory J. Riggins1,5,
  40. Rachel Karchin4,
  41. Giovanni Parmigiani20,
  42. Darell D. Bigner17,
  43. Hai Yan17,
  44. Nick Papadopoulos1,
  45. Bert Vogelstein1,,
  46. Kenneth W. Kinzler1,,
  47. Victor E. Velculescu1,
  1. 1Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.
  2. 2Texas Children’s Cancer Center and Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, Houston TX 77030, USA.
  3. 3Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  4. 4Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21218, USA.
  5. 5Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  6. 6GeneGo, Inc., St. Joseph, St. Joseph, MI 49085, USA.
  7. 7Beckman Coulter Genomics, Inc., Danvers, MA 01923, USA.
  8. 8Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
  9. 9Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
  10. 10Department of Pathology, Division of Neuropathology, University of California–San Diego, San Diego, CA, USA.
  11. 11Department of Neurological Surgery, University of California–San Francisco, San Francisco, CA 94143, USA.
  12. 12Department of Neurology, School of Medicine of University of Sao Paulo, Sao Paulo, Brazil.
  13. 13Pio XII Foundation, Barretos Cancer Hospital, Sao Paulo, Brazil.
  14. 14Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  15. 15Division of Neurosurgery, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  16. 16Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  17. 17The Preston Robert Tisch Brain Tumor Center, Pediatric Brain Tumor Foundation Institute, Department of Pathology, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
  18. 18Division of Neurosurgery and Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G1L7, Canada.
  19. 19Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  20. 20Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
  1. To whom correspondence should be addressed: velculescu{at}jhmi.edu (V.E.V.); kinzlke{at}jhmi.edu (K.W.K.); vogelbe{at}gmail.com (B.V.)
  1. * These authors contributed equally to this work.

  • Present address: Department of Pathology and Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA.

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