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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Science  28 Jan 2011:
Vol. 331, Issue 6016, pp. 456-461
DOI: 10.1126/science.1196371

Article Information

vol. 331 no. 6016 456-461

PubMed: 
Print ISSN: 
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History: 
  • Received for publication August 11, 2010
  • Accepted for publication December 8, 2010
  • .

Article Versions

Author Information

  1. Daniel F. Egan1,
  2. David B. Shackelford1,
  3. Maria M. Mihaylova1,2,
  4. Sara Gelino4,
  5. Rebecca A. Kohnz1,
  6. William Mair1,
  7. Debbie S. Vasquez1,
  8. Aashish Joshi5,
  9. Dana M. Gwinn1,
  10. Rebecca Taylor1,
  11. John M. Asara6,
  12. James Fitzpatrick3,
  13. Andrew Dillin1,2,
  14. Benoit Viollet7,
  15. Mondira Kundu5,
  16. Malene Hansen4,
  17. Reuben J. Shaw1,2,*
  1. 1Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  2. 2Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  3. 3Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  4. 4Graduate School of Biomedical Sciences, Del E. Webb Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
  5. 5Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
  6. 6Division of Signal Transduction, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Inserm, U1016, Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France.
  1. *To whom correspondence should be addressed. E-mail: shaw{at}salk.edu

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