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DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

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Science  04 Mar 2011:
Vol. 331, Issue 6021, pp. 1199-1203
DOI: 10.1126/science.1200609

Article Information

vol. 331 no. 6021 1199-1203

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History: 
  • Received for publication November 18, 2010
  • Accepted for publication January 10, 2011

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Author Information

  1. Yuchen Jiao1,*,
  2. Chanjuan Shi2,*,
  3. Barish H. Edil3,
  4. Roeland F. de Wilde2,
  5. David S. Klimstra4,
  6. Anirban Maitra5,
  7. Richard D. Schulick3,
  8. Laura H. Tang4,
  9. Christopher L. Wolfgang3,
  10. Michael A. Choti3,
  11. Victor E. Velculescu1,
  12. Luis A. Diaz Jr.1,6,
  13. Bert Vogelstein1,
  14. Kenneth W. Kinzler1,,
  15. Ralph H. Hruban5,,
  16. Nickolas Papadopoulos1,
  1. 1Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.
  2. 2Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
  3. 3Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
  4. 4Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  5. 5Departments of Pathology and Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
  6. 6Swim Across America Laboratory, Johns Hopkins University, Baltimore, MD 21231, USA.
  1. To whom correspondence should be addressed. E-mail: npapado1{at}jhmi.edu (N.P.); rhruban{at}jhmi.edu (R.H.H.); kinzlke{at}jhmi.edu (K.W.K.)
  1. * These authors contributed equally to this work.

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