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CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

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Science  25 Mar 2011:
Vol. 331, Issue 6024, pp. 1612-1616
DOI: 10.1126/science.1198443

Article Information

vol. 331 no. 6024 1612-1616

Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 29, 2010
  • Accepted for publication February 14, 2011
  • .

Author Information

  1. Gregory L. Beatty1,2,6,
  2. Elena G. Chiorean3,
  3. Matthew P. Fishman1,
  4. Babak Saboury5,
  5. Ursina R. Teitelbaum2,6,
  6. Weijing Sun2,6,
  7. Richard D. Huhn4,
  8. Wenru Song4,
  9. Dongguang Li4,
  10. Leslie L. Sharp4,
  11. Drew A. Torigian2,5,
  12. Peter J. O’Dwyer2,6,
  13. Robert H. Vonderheide1,2,6,*
  1. 1Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
  2. 2Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  3. 3Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  4. 4Pfizer Corporation, New London, CT 06320, USA.
  5. 5Department of Radiology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  6. 6Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  1. *To whom correspondence should be addressed. E-mail: rhv{at}exchange.upenn.edu

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