Progranulin Resolves Inflammation

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Science  22 Apr 2011:
Vol. 332, Issue 6028, pp. 427-428
DOI: 10.1126/science.1205992

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The cytokine tumor necrosis factor α (TNFα) is a major driver of rheumatoid arthritis and related inflammatory diseases. Therapeutic agents that block TNFα or mimic a soluble receptor for the cytokine are effective in these diseases, but whether other endogenous modulators of TNFα action exist that could be targets for therapeutic intervention is not clear. On page 478 of this issue, Tang et al. (1) show that progranulin, a secreted molecule with some cytokine-like properties, binds to TNF receptors and limits the action of TNFα in inflammatory arthritis.