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The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

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Science  22 Apr 2011:
Vol. 332, Issue 6028, pp. 478-484
DOI: 10.1126/science.1199214

Article Information

vol. 332 no. 6028 478-484

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History: 
  • Received for publication October 18, 2010
  • Accepted for publication February 28, 2011

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Author Information

  1. Wei Tang1,2,*,
  2. Yi Lu1,2,*,
  3. Qing-Yun Tian1,*,
  4. Yan Zhang1,
  5. Feng-Jin Guo1,,
  6. Guang-Yi Liu1,
  7. Nabeel Muzaffar Syed1,
  8. Yongjie Lai1,
  9. Edward Alan Lin1,
  10. Li Kong1,
  11. Jeffrey Su3,
  12. Fangfang Yin4,,
  13. Ai-Hao Ding4,
  14. Alexandra Zanin-Zhorov5,
  15. Michael L. Dustin5,
  16. Jian Tao6,
  17. Joseph Craft6,
  18. Zhinan Yin7,
  19. Jian Q. Feng8,
  20. Steven B. Abramson9,
  21. Xiu-Ping Yu2,
  22. Chuan-ju Liu1,10,§
  1. 1Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.
  2. 2Institute of Pathogenic Biology, Shandong University School of Medicine, Jinan, Shandong 250012, China.
  3. 3Cytovance Biologics, Oklahoma City, OK 73104, USA.
  4. 4Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.
  5. 5Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
  6. 6Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
  7. 7College of Life Sciences, Nankai University, Tianjin 300071, China.
  8. 8Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, TX 75246, USA.
  9. 9Division of Rheumatology, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.
  10. 10Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
  1. §To whom correspondence should be addressed. E-mail: chuanju.liu{at}med.nyu.edu
  1. * These authors contributed equally to this work.

  • Present address: Chongqing Medical University, Chongqing, 400016, China.

  • Present address: SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.

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