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Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

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Science  03 Jun 2011:
Vol. 332, Issue 6034, pp. 1190-1192
DOI: 10.1126/science.1203799

Article Information

vol. 332 no. 6034 1190-1192

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History: 
  • Received for publication February 3, 2011
  • Accepted for publication April 25, 2011
  • .

Author Information

  1. Hsin-Hung Chou1,*,
  2. Hsuan-Chao Chiu2,
  3. Nigel F. Delaney1,
  4. Daniel Segrè2,3,
  5. Christopher J. Marx1,4,
  1. 1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  2. 2Graduate Program in Bioinformatics, Boston University, Boston, MA 02215, USA.
  3. 3Department of Biology and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
  4. 4Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.
  1. To whom correspondence should be addressed. E-mail: cmarx{at}oeb.harvard.edu
  • * Present address: Institute of Molecular Systems Biology, ETH Zürich, CH-8093 Zürich, Switzerland.

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