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Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

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Science  03 Jun 2011:
Vol. 332, Issue 6034, pp. 1193-1196
DOI: 10.1126/science.1203801

Article Information

vol. 332 no. 6034 1193-1196

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History: 
  • Received for publication February 3, 2011
  • Accepted for publication April 25, 2011
  • .

Author Information

  1. Aisha I. Khan1,*,,
  2. Duy M. Dinh1,*,
  3. Dominique Schneider2,3,
  4. Richard E. Lenski4,
  5. Tim F. Cooper1,
  1. 1Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
  2. 2Laboratoire Adaptation et Pathogénie des Microorganismes, Université Joseph Fourier, Institut Jean Roget, F-38041 Grenoble, France.
  3. 3CNRS UMR5163, F-38041 Grenoble, France.
  4. 4Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
  1. To whom correspondence should be addressed. E-mail: tfcooper{at}uh.edu
  1. * These authors contributed equally to this work.

  • Present address: University of Texas Medical Branch, Galveston, TX 77555, USA.

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