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The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

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Science  10 Jun 2011:
Vol. 332, Issue 6035, pp. 1317-1322
DOI: 10.1126/science.1199498

Article Information

vol. 332 no. 6035 1317-1322

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 25, 2010
  • Accepted for publication April 22, 2011
  • .

Author Information

  1. Peggy P. Hsu1,2,
  2. Seong A. Kang1,
  3. Jonathan Rameseder3,4,
  4. Yi Zhang5,6,
  5. Kathleen A. Ottina1,7,
  6. Daniel Lim4,
  7. Timothy R. Peterson1,2,
  8. Yongmun Choi5,8,
  9. Nathanael S. Gray5,8,
  10. Michael B. Yaffe2,4,
  11. Jarrod A. Marto5,6,8,
  12. David M. Sabatini1,2,4,7,*
  1. 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
  2. 2Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  3. 3Computational and Systems Biology Initiative, MIT, Cambridge, MA 02139, USA.
  4. 4David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
  5. 5Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), 250 Longwood Avenue, Boston, MA 02115, USA.
  6. 6Blais Proteomics Center, DFCI, 250 Longwood Avenue, Boston, MA 02115, USA.
  7. 7Howard Hughes Medical Institute, MIT, Cambridge, MA 02139,USA.
  8. 8Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA.
  1. *To whom correspondence should be addressed. E-mail: sabatini{at}wi.mit.edu

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