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Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

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Science  10 Jun 2011:
Vol. 332, Issue 6035, pp. 1322-1326
DOI: 10.1126/science.1199484

Article Information

vol. 332 no. 6035 1322-1326

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History: 
  • Received for publication October 25, 2010
  • Accepted for publication April 22, 2011

Author Information

  1. Yonghao Yu1,
  2. Sang-Oh Yoon1,*,
  3. George Poulogiannis2,
  4. Qian Yang1,3,
  5. Xiaoju Max Ma1,,
  6. Judit Villén1,,
  7. Neil Kubica1,§,
  8. Gregory R. Hoffman1,
  9. Lewis C. Cantley2,
  10. Steven P. Gygi1,,
  11. John Blenis1,
  1. 1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  3. 3Harvard School of Dental Medicine, Boston, MA 02115, USA.
  1. To whom correspondence should be addressed. E-mail: steven_gygi{at}hms.harvard.edu (S.P.G); john_blenis{at}hms.harvard.edu (J.B.)
  • * Present address: Department of Cancer and Cell Biology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.

  • Present address: Department of Research Oncology Diagnostics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

  • Present address: Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

  • § Present address: Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

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