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Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

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Science  15 Jul 2011:
Vol. 333, Issue 6040, pp. 348-353
DOI: 10.1126/science.1205822

Article Information

vol. 333 no. 6040 348-353

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History: 
  • Received for publication March 18, 2011
  • Accepted for publication May 20, 2011

Author Information

  1. Farren J. Isaacs1,*,,
  2. Peter A. Carr2,3,*,§,
  3. Harris H. Wang1,4,5,6,*,
  4. Marc J. Lajoie1,7,
  5. Bram Sterling2,3,
  6. Laurens Kraal1,
  7. Andrew C. Tolonen1,
  8. Tara A. Gianoulis1,6,
  9. Daniel B. Goodman1,5,
  10. Nikos B. Reppas8,
  11. Christopher J. Emig9,
  12. Duhee Bang10,
  13. Samuel J. Hwang11,
  14. Michael C. Jewett1,12,
  15. Joseph M. Jacobson2,3,
  16. George M. Church1,6
  1. 1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Center for Bits and Atoms, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  3. 3MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  4. 4Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.
  5. 5Program in Medical Engineering and Medical Physics, Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
  6. 6Wyss Institute, Harvard University, Cambridge, MA 02115, USA.
  7. 7Program in Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  8. 8Joule Unlimited, Cambridge, MA 02139, USA.
  9. 9Department of Bioengineering, Stanford University, Palo Alto, CA 94305, USA.
  10. 10Department of Chemistry, Yonsei University, Shinchon 134, Seoul 120-749, Korea.
  11. 11Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  12. 12Department of Chemical and Biological Engineering and Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA.
  1. To whom correspondence should be addressed. E-mail: farren.isaacs{at}yale.edu (F.J.I.); carr{at}mit.edu (P.A.C.)
  1. * These authors contributed equally to this work.

  • Present address: Department of Molecular, Cellular and Developmental Biology, Systems Biology Institute, Yale University, New Haven, CT 06520, USA.

  • § Present address: Lincoln Laboratory, Massachusetts Institute of Technology, Lexington, MA 02420, USA.

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