Research Article

Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network

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Science  29 Jul 2011:
Vol. 333, Issue 6042, pp. 596-601
DOI: 10.1126/science.1203659

Article Information

vol. 333 no. 6042 596-601

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History: 
  • Received for publication February 1, 2011
  • Accepted for publication June 6, 2011
  • .

Author Information

  1. M. Shahid Mukhtar1,*,,
  2. Anne-Ruxandra Carvunis2,3,4,*,
  3. Matija Dreze2,3,5,*,
  4. Petra Epple1,*,
  5. Jens Steinbrenner6,
  6. Jonathan Moore7,
  7. Murat Tasan8,
  8. Mary Galli9,
  9. Tong Hao2,3,
  10. Marc T. Nishimura1,
  11. Samuel J. Pevzner2,3,10,11,
  12. Susan E. Donovan6,,
  13. Lila Ghamsari2,3,
  14. Balaji Santhanam2,3,
  15. Viviana Romero2,3,
  16. Matthew M. Poulin2,3,
  17. Fana Gebreab2,3,
  18. Bryan J. Gutierrez2,3,
  19. Stanley Tam2,3,
  20. Dario Monachello12,
  21. Mike Boxem13,
  22. Christopher J. Harbort1,§,
  23. Nathan McDonald1,
  24. Lantian Gai9,
  25. Huaming Chen9,
  26. Yijian He1,
  27. European Union Effectoromics Consortium,
  28. Jean Vandenhaute5,
  29. Frederick P. Roth2,14,,
  30. David E. Hill2,3,
  31. Joseph R. Ecker9,15,
  32. Marc Vidal2,3,,
  33. Jim Beynon6,7,,
  34. Pascal Braun2,3,,
  35. Jeffery L. Dangl1,16,17,18,
  1. 1Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  2. 2Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  3. 3Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Computational and Mathematical Biology Group, TIMC-IMAG, CNRS UMR5525 and Université de Grenoble, Faculté de Médecine, 38706 La Tronche cedex, France.
  5. 5Unité de Recherche en Biologie Moléculaire, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Wallonia-Brussels Federation, Belgium.
  6. 6School of Life Sciences, University of Warwick, Wellesbourne, Warwick, CV35 9EF, UK.
  7. 7Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry, CV4 7AL, UK.
  8. 8Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  9. 9Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  10. 10Biomedical Engineering Department, Boston University, Boston, MA 02215, USA.
  11. 11Boston University School of Medicine, Boston, MA 02118, USA.
  12. 12Unité Mixte de Recherche en Génomique Végétale (URGV), UMR, Institut National de la Recherche Agronomique (INRA), Université d’Evry–Val d'Essonne—European Research Laboratory (UEVE–ERL), CNRS, 91057 Evry Cedex, France.
  13. 13Utrecht University, 3584 CH Utrecht, Netherlands.
  14. 14Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  15. 15Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  16. 16Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  17. 17Carolina Center for Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  18. 18Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  1. To whom correspondence should be addressed. E-mails: dangl{at}email.unc.edu (J.L.D.); pascal_braun{at}dfci.harvard.edu (P.B.); jim.beynon{at}warwick.ac.uk (J.B.); marc_vidal{at}dfci.harvard.edu (M.V.)
  1. * These authors contributed equally to this project.

  • Present address: Department of Biology, CH106, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.

  • Present address: ADAS Boxworth Research Centre, Boxworth, Cambridgeshire CB23 4NN, UK.

  • § Present address: Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany.

  • ∥Present address: Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S3E1, Canada, and Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Ontario M5G1X5, Canada.

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