05 August 2011
Vol 333, Issue 6043

About The Cover

Cover image expansion

COVER A pair of chemical compounds (light blue and purple) target wild-type and mutant forms of the Plasmodium falciparum chloroquine resistance transporter, which mediates the parasite's (yellow) resistance to the widely used antimalarial drug. Using high-throughput chemical and genetic analyses, Yuan et al. identify potential new antimalarial drugs that could be used in combination to suppress the development of drug resistance. 724 [Image: Ethan Tyler and Alan Hoofring, Division of Medical Arts, National Institutes of Health]