MED23 Mutation Links Intellectual Disability to Dysregulation of Immediate Early Gene Expression

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Science  26 Aug 2011:
Vol. 333, Issue 6046, pp. 1161-1163
DOI: 10.1126/science.1206638

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  • Molecular Mechanism for Genetic Mutation Remains Unknown

    I read with great interest the Research Article by S. Hashimoto et al., "MED23 mutation links intellectual disability to dysregulation of immediate early gene expression" (26 August 2011, p. 1161), in which the authors uncovered a single mutation in the Mammalian Mediator (MED) subunit MED23 that alters the interaction between enhancer-bound transcription factors and Mediator.

    I would like to make one ob...

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    Competing Interests: None declared.

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