Report

MED23 Mutation Links Intellectual Disability to Dysregulation of Immediate Early Gene Expression

See allHide authors and affiliations

Science  26 Aug 2011:
Vol. 333, Issue 6046, pp. 1161-1163
DOI: 10.1126/science.1206638

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed.  Please read our Terms of Service before submitting your own eLetter.

Compose eLetter

Plain text

  • Plain text
    No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests
CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Image CAPTCHA
Enter the characters shown in the image.

Vertical Tabs

  • Molecular Mechanism for Genetic Mutation Remains Unknown

    I read with great interest the Research Article by S. Hashimoto et al., "MED23 mutation links intellectual disability to dysregulation of immediate early gene expression" (26 August 2011, p. 1161), in which the authors uncovered a single mutation in the Mammalian Mediator (MED) subunit MED23 that alters the interaction between enhancer-bound transcription factors and Mediator.

    I would like to make one ob...

    Show More
    Competing Interests: None declared.