16 September 2011
Vol 333, Issue 6049

About The Cover

Cover image expansion

COVER Maturation of human antibodies from germline recombinant (gray ribbon structure), along four lineages (orange, yellow, green, and blue), into potent neutralizers of HIV-1. A mature antibody variable domain is shown binding its target, HIV-1 envelope glycoprotein gp120 (red ribbon structure). Deep sequencing and structural bioinformatics of the antibody repertoires of HIV-infected individuals uncover the genetic record for the development of broadly neutralizing HIV-1 immunity. See p. 1593 Image: Jonathan Stuckey/Vaccine Research Center, National Institute of Allergy and Infectious Diseases/NIH