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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

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Science  16 Sep 2011:
Vol. 333, Issue 6049, pp. 1633-1637
DOI: 10.1126/science.1207227

Article Information

vol. 333 no. 6049 1633-1637

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History: 
  • Received for publication April 19, 2011
  • Accepted for publication June 21, 2011
  • .

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Author Information

  1. Johannes F. Scheid1,2,
  2. Hugo Mouquet1,*,
  3. Beatrix Ueberheide3,*,
  4. Ron Diskin4,*,
  5. Florian Klein1,
  6. Thiago Y. K. Oliveira1,
  7. John Pietzsch1,5,
  8. David Fenyo3,
  9. Alexander Abadir1,
  10. Klara Velinzon1,
  11. Arlene Hurley6,
  12. Sunnie Myung3,
  13. Farid Boulad7,
  14. Pascal Poignard8,9,
  15. Dennis R. Burton8,10,
  16. Florencia Pereyra10,11,
  17. David D. Ho12,
  18. Bruce D. Walker10,11,12,
  19. Michael S. Seaman14,
  20. Pamela J. Bjorkman4,12,
  21. Brian T. Chait3,
  22. Michel C. Nussenzweig1,12,
  1. 1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  2. 2Charité Universitätsmedizin, D-10117 Berlin, Germany.
  3. 3Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10065, USA.
  4. 4Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
  5. 5Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, D14195 Berlin, Germany.
  6. 6Rockefeller University Hospital, The Rockefeller University, New York, NY10065, USA.
  7. 7Bone Marrow Transplant Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  8. 8Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  9. 9International AIDS Vaccine Initiative, New York, NY 10028, USA.
  10. 10Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02129, USA.
  11. 11Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
  12. 12Howard Hughes Medical Institute.
  13. 13Aaron Diamond Aids Research Center, New York, NY 10065, USA.
  14. 14Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  1. To whom correspondence should be addressed. E-mail: nussen{at}mail.rockefeller.edu
  1. * These authors contributed equally to this work.

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