Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

Seung Chul Shin; Sung-Hee Kim; Hyejin You; Boram Kim; Aeri C. Kim; Kyung-Ah Lee; Joo-Heon Yoon; Ji-Hwan Ryu; Won-Jae Lee

doi:10.1126/science.1212782

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Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

Seung Chul Shin¹,³,*,†,
Sung-Hee Kim¹,†,
Hyejin You¹,²,
Boram Kim¹,²,
Aeri C. Kim¹,²,
Kyung-Ah Lee¹,
Joo-Heon Yoon³,
Ji-Hwan Ryu³,
Won-Jae Lee¹,‡

¹School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.
²Department of Bioinspired Science and Division of Life and Pharmaceutical Science, Ewha Woman’s University, Seoul 120-750, South Korea.
³Research Center for Human Natural Defense System, Yonsei University College of Medicine, CPO Box 8044 Seoul, South Korea.

↵‡To whom correspondence should be addressed. E-mail: lwj{at}snu.ac.kr

↵† These authors contributed equally to this work.

↵* Present address: Korea Polar Research Institute, Incheon 406-840, South Korea.

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Science 04 Nov 2011:
Vol. 334, Issue 6056, pp. 670-674
DOI: 10.1126/science.1212782

Seung Chul Shin

1School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.

3Research Center for Human Natural Defense System, Yonsei University College of Medicine, CPO Box 8044 Seoul, South Korea.

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Sung-Hee Kim

1School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.

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Hyejin You

1School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.

2Department of Bioinspired Science and Division of Life and Pharmaceutical Science, Ewha Woman’s University, Seoul 120-750, South Korea.

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Boram Kim

1School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.

2Department of Bioinspired Science and Division of Life and Pharmaceutical Science, Ewha Woman’s University, Seoul 120-750, South Korea.

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Aeri C. Kim

1School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.

2Department of Bioinspired Science and Division of Life and Pharmaceutical Science, Ewha Woman’s University, Seoul 120-750, South Korea.

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Kyung-Ah Lee

1School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.

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Joo-Heon Yoon

3Research Center for Human Natural Defense System, Yonsei University College of Medicine, CPO Box 8044 Seoul, South Korea.

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Ji-Hwan Ryu

3Research Center for Human Natural Defense System, Yonsei University College of Medicine, CPO Box 8044 Seoul, South Korea.

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Won-Jae Lee

1School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.

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For correspondence: lwj@snu.ac.kr

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Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

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