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Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

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Science  18 Nov 2011:
Vol. 334, Issue 6058, pp. 982-986
DOI: 10.1126/science.1211037

Article Information

vol. 334 no. 6058 982-986

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 12, 2011
  • Accepted for publication September 27, 2011
  • .

Author Information

  1. Dao Nguyen1,,
  2. Amruta Joshi-Datar2,
  3. Francois Lepine3,
  4. Elizabeth Bauerle2,
  5. Oyebode Olakanmi4,
  6. Karlyn Beer2,
  7. Geoffrey McKay1,
  8. Richard Siehnel2,
  9. James Schafhauser1,
  10. Yun Wang5,
  11. Bradley E. Britigan4,6,*,
  12. Pradeep K. Singh2
  1. 1Departments of Medicine, Microbiology and Immunology,McGill University, 1650 Cedar Avenue, L11.513, Montreal, Quebec H3G 1A4, Canada.
  2. 2Departments of Medicine and Microbiology, University of Washington School of Medicine, 1959 Northeast Pacific Street, Seattle, WA 98195–7242, USA.
  3. 3Department of Microbiology, INRS Armand Frappier, 531 Boulevarde des Prairies, Laval, Quebec H7V 1B7, Canada.
  4. 4Department of Internal Medicine, University of Cincinnati, Medical Sciences Building 6065, Post Office Box 670557, Cincinnati, OH 45267, USA.
  5. 5Department of Civil and Environmental Engineering, Northwestern University, A222 Technological Institute, 2145 Sheridan Road, Evanston, IL 60208, USA.
  6. 6Veterans Administration Medical Center–Cincinnati, 3200 Vine Street, Cincinnati, OH 45220, USA.
  1. To whom correspondence should be addressed. E-mail: dao.nguyen{at}mcgill.ca
  • * Present address: College of Medicine, University of Nebraska, 42nd and Emile, Omaha, NE 68198, USA.

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