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Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

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Science  18 Nov 2011:
Vol. 334, Issue 6058, pp. 993-996
DOI: 10.1126/science.1211053

Article Information

vol. 334 no. 6058 993-996

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Print ISSN: 
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History: 
  • Received for publication July 12, 2011
  • Accepted for publication September 30, 2011
  • .

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Author Information

  1. Jian Xu1,2,
  2. Cong Peng1,*,
  3. Vijay G. Sankaran1,5,*,
  4. Zhen Shao1,
  5. Erica B. Esrick1,3,
  6. Bryan G. Chong1,
  7. Gregory C. Ippolito4,
  8. Yuko Fujiwara1,2,
  9. Benjamin L. Ebert3,
  10. Philip W. Tucker4,
  11. Stuart H. Orkin1,2,
  1. 1Division of Hematology/Oncology, Children’s Hospital Boston and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Howard Hughes Medical Institute, Boston, MA 02115, USA.
  3. 3Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
  5. 5Broad Institute and Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  1. To whom correspondence should be addressed. E-mail: stuart_orkin{at}dfci.harvard.edu
  1. * These authors contributed equally to this work.

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