Research Article

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

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Science  25 Nov 2011:
Vol. 334, Issue 6059, pp. 1097-1103
DOI: 10.1126/science.1213256

Article Information

vol. 334 no. 6059 1097-1103

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History: 
  • Received for publication August 29, 2011
  • Accepted for publication October 6, 2011
  • .

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Author Information

  1. Robert Pejchal1,*,
  2. Katie J. Doores2,3,*,
  3. Laura M. Walker2,*,
  4. Reza Khayat1,*,
  5. Po-Ssu Huang4,*,
  6. Sheng-Kai Wang5,
  7. Robyn L. Stanfield1,
  8. Jean-Philippe Julien1,
  9. Alejandra Ramos2,
  10. Max Crispin6,
  11. Rafael Depetris7,
  12. Umesh Katpally8,
  13. Andre Marozsan8,
  14. Albert Cupo8,
  15. Sebastien Maloveste9,
  16. Yan Liu10,
  17. Ryan McBride11,
  18. Yukishige Ito12,
  19. Rogier W. Sanders7,13,
  20. Cassandra Ogohara4,
  21. James C. Paulson11,
  22. Ten Feizi10,
  23. Christopher N. Scanlan6,
  24. Chi-Huey Wong5,
  25. John P. Moore7,
  26. William C. Olson8,
  27. Andrew B. Ward1,
  28. Pascal Poignard2,14,
  29. William R. Schief2,4,
  30. Dennis R. Burton2,3,,
  31. Ian A. Wilson1,
  1. 1Department of Molecular Biology, Skaggs Institute for Chemical Biology, and International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  2. 2Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  3. 3Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02129, USA.
  4. 4Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  5. 5Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
  6. 6Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
  7. 7Weill Medical College of Cornell University, New York, NY 10021, USA.
  8. 8Progenics Pharmaceuticals, Tarrytown, NY 10591, USA.
  9. 9Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  10. 10Glycosciences Laboratory, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.
  11. 11Department of Physiological Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
  12. 12RIKEN Advanced Science Institute and Exploratory Research for Advanced Technology, Japan Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  13. 13Department of Medical Microbiology, Academic Medical Center, Amsterdam, Netherlands.
  14. 14International AIDS Vaccine Initiative, New York, NY 10038, USA.
  1. To whom correspondence should be addressed: E-mail: burton{at}scripps.edu (D.R.B.); wilson{at}scripps.edu (I.A.W.)
  1. * These authors contributed equally to this work.

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