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Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

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Science  25 Nov 2011:
Vol. 334, Issue 6059, pp. 1129-1133
DOI: 10.1126/science.1206727

Article Information

vol. 334 no. 6059 1129-1133

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History: 
  • Received for publication April 8, 2011
  • Accepted for publication October 7, 2011

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Author Information

  1. Triona Ni Chonghaile1,*,
  2. Kristopher A. Sarosiek1,*,
  3. Thanh-Trang Vo1,4,
  4. Jeremy A. Ryan1,
  5. Anupama Tammareddi1,
  6. Victoria Del Gaizo Moore2,
  7. Jing Deng1,
  8. Kenneth C. Anderson1,
  9. Paul Richardson1,
  10. Yu-Tzu Tai1,
  11. Constantine S. Mitsiades1,
  12. Ursula A. Matulonis1,
  13. Ronny Drapkin1,5,
  14. Richard Stone1,
  15. Daniel J. DeAngelo1,
  16. David J. McConkey3,
  17. Stephen E. Sallan6,
  18. Lewis Silverman6,
  19. Michelle S. Hirsch5,
  20. Daniel Ruben Carrasco1,
  21. Anthony Letai1,
  1. 1Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
  2. 2Department of Chemistry, Elon University, 400 South O’Kelly Avenue, Elon, NC 27244, USA.
  3. 3Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  4. 4Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  5. 5Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
  6. 6Department of Pediatric Hematology/Oncology, Children’s Hospital Boston, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
  1. To whom correspondence should be addressed. E-mail: anthony_letai{at}dfci.harvard.edu
  1. * These authors contributed equally to this work.

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