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Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design

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Science  02 Dec 2011:
Vol. 334, Issue 6060, pp. 1289-1293
DOI: 10.1126/science.1213782

Article Information

vol. 334 no. 6060 1289-1293

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 9, 2011
  • Accepted for publication October 18, 2011
  • .

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Author Information

  1. Ron Diskin1,
  2. Johannes F. Scheid2,3,
  3. Paola M. Marcovecchio1,
  4. Anthony P. West Jr.1,
  5. Florian Klein2,
  6. Han Gao1,
  7. Priyanthi N. P. Gnanapragasam1,
  8. Alexander Abadir2,
  9. Michael S. Seaman4,
  10. Michel C. Nussenzweig2,5,
  11. Pamela J. Bjorkman1,6,*
  1. 1Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
  2. 2Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  3. 3Charite Universitätsmedizin, D-10117 Berlin, Germany.
  4. 4Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  5. 5Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
  6. 6Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
  1. *To whom correspondence should be addressed. E-mail: bjorkman{at}caltech.edu

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