Research Article

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

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Science  09 Dec 2011:
Vol. 334, Issue 6061, pp. 1372-1377
DOI: 10.1126/science.1211936

Article Information

vol. 334 no. 6061 1372-1377

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History: 
  • Received for publication July 29, 2011
  • Accepted for publication October 6, 2011

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Author Information

  1. Stephan Meister1,*,
  2. David M. Plouffe2,*,
  3. Kelli L. Kuhen2,
  4. Ghislain M. C. Bonamy2,
  5. Tao Wu2,,
  6. S. Whitney Barnes2,
  7. Selina E. Bopp1,
  8. Rachel Borboa2,
  9. A. Taylor Bright1,3,
  10. Jianwei Che2,
  11. Steve Cohen2,
  12. Neekesh V. Dharia1,
  13. Kerstin Gagaring2,
  14. Montip Gettayacamin4,
  15. Perry Gordon2,
  16. Todd Groessl2,
  17. Nobutaka Kato2,
  18. Marcus C. S. Lee5,
  19. Case W. McNamara2,
  20. David A. Fidock5,6,
  21. Advait Nagle2,
  22. Tae-gyu Nam7,,
  23. Wendy Richmond2,
  24. Jason Roland2,
  25. Matthias Rottmann8,9,
  26. Bin Zhou2,
  27. Patrick Froissard10,11,
  28. Richard J. Glynne2,
  29. Dominique Mazier10,11,12,
  30. Jetsumon Sattabongkot13,
  31. Peter G. Schultz7,
  32. Tove Tuntland2,
  33. John R. Walker2,
  34. Yingyao Zhou2,
  35. Arnab Chatterjee2,
  36. Thierry T. Diagana14,
  37. Elizabeth A. Winzeler1,2,§
  1. 1Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.
  2. 2Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
  3. 3Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA.
  4. 4Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok 10400, Thailand.
  5. 5Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
  6. 6Department of Medicine (Division of Infectious Diseases), Columbia University Medical Center, New York, NY 10032, USA.
  7. 7Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
  8. 8Parasite Chemotherapy, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.
  9. 9University of Basel, CH-4003 Basel, Switzerland.
  10. 10INSERM, U945, Paris, France.
  11. 11Université Pierre et Marie Curie–Paris (UPMC), UMR S 945 Paris, France.
  12. 12Assistance Publique–Hôpitaux de Paris, Groupe hospitalier Pitié-Salpêtrière, Service Parasitologie-Mycologie, Paris, France.
  13. 13Entomology Department, AFRIMS, Bangkok 10400, Thailand.
  14. 14Novartis Institutes for Tropical Disease, Singapore.
  1. §To whom correspondence may be addressed. E-mail: winzeler{at}scripps.edu or ewinzele{at}gnf.org
  1. * These authors contributed equally to this work.

  • Present address: Life Technologies, 5781 Van Allen Way, Carlsbad, CA 92008, USA.

  • Present address: Gyeonggi Bio-Center, Suwon, Gyeonggi-do 443-270, Korea and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 426-791, Korea.

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