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Science  20 Jan 2012:
Vol. 335, Issue 6066, pp. 357
DOI: 10.1126/science.335.6066.357-a

&um;Drop Plate

The &um;Drop Plate is for the quick and easy measurement of samples down to 2 &um;L. The &um;Drop Plate provides a straightforward way of analyzing up to 16 microliter-scale samples simultaneously. The fixed-light path of the plate allows direct calculation of nucleic acid concentrations of the samples. Furthermore, users can detect dsDNA from a few micrograms to a few milligrams per milliliter, without needing to perform any dilutions. These characteristics make the &um;Drop Plate an ideal tool for photometric DNA or RNA quantitation and purity analysis. Samples are easily pipetted onto the &um;Drop Plate using a single- or eight-channel pipette. The plate is easily wiped clean, making it convenient for serial measurements. Additionally, the &um;Drop Plate is equipped with a cuvette slot, enabling endpoint, spectral, and kinetic measurements in a standard rectangular cuvette. The &um;Drop Plate has been designed for use with the Thermo Scientific Multiskan GO UV/Vis microplate and cuvette spectrophotometer, as well as the Thermo Scientific Varioskan Flash spectral scanning multimode reader.

Biomolecular Imaging

Two new biomolecular imaging systems are available: the Typhoon FLA 9500 for imaging of multifluorescent, chemifluorescent, radioisotope-labeled, and colorimetric samples, and the Typhoon FLA 7000 IP for the dedicated study of radioisotope labeled samples. The Typhoon FLA 9500 is a versatile, high throughput laser scanner ideally suited to a multiuser environment. With a pixel resolution of up to 10 &um;m and a linear signal response over five orders of magnitude, the system provides precise quantitation in gels, blots, tissue sections, and arrays. A scanning area of 40 ×46 cm enables simultaneous imaging of 20 samples. The Typhoon 7000 IP is an entry-level scanner that enables high-speed, sensitive detection and quantitation of radioisotope-labeled samples. The model can scan over 10 image plates per hour, generating 16-bit images at up to 25 &um;m pixel resolution using storage phosphor screen technology.

IsoElectric Focusing System

The PROTEAN i12 IEF system is the industry's only isoelectric focusing (IEF) system that is designed to simultaneously run up to 12 immobilized pH gradient (IPG) strips in 12 independently programmed lanes. For the best 2-D gel electrophoresis results, researchers optimize their sample preparation and first-dimension isoelectric focusing conditions to ensure adequate separation of complex samples. Because the optimal IEF conditions for different protein samples can vary significantly, each set of conditions must be tested separately. The PROTEAN i12 IEF system controls lanes separately, allowing researchers to set precise current limits for each lane. This enables the system to run different samples and pH ranges simultaneously while preventing differing samples from affecting each other, resulting in more reliable and reproducible focusing. The system also lets researchers test several optimization conditions simultaneously and run samples from different experiments together, both of which will speed their time to results.

Lentiviral Biosensors

A suite of LentiBrite lentiviral biosensors, prepackaged lentiviral particles encoding proteins fluorescently tagged with green or red fluorescent protein (GFP or RFP) are now available. The initial group of biosensors encode proteins responsible for cell structure such as actin and tubulin, a central marker of autophagy-LC3, and proteins that mark the onset of apoptosis. The biosensors enable detection of the presence or absence of a particular protein as well as the subcellular location of the protein in live cells under various states either by fluorescent microscopy or time-lapse video capture. Use of lentivirus to deliver fluorescently-tagged proteins into cells offers higher-efficiency transfection as compared with traditional chemical-based and other nonviral-based methods. In addition, the virus particles can be used to transfect dividing, nondividing, and difficult-to-transfect cells, such as primary and stem cells, leading to long-term, stable expression of the transgene with low immunogenicity.

PCR Master Mix

The GoTaq Long PCR Master Mix is an optimized enzyme mixture for improved long-range polymerase chain reaction (PCR). The new kit enhances PCR yield, sensitivity, and specificity and enables efficient amplification of up to 40 kb from lambda DNA or 30 kb from human genomic DNA. The new master mix is ideal for cloning genes, mutational analysis, and DNA sequencing. The GoTaq Long PCR Master Mix contains the high-performance GoTaq Hot Start Polymerase in a specially formulated mixture with a second proprietary thermal stable proofreading polymerase. The presence of a proofreading enzyme to repair DNA mismatches in the presence of a highly processive polymerase allows increased DNA elongation, resulting in longer DNA amplification. GoTaq Long PCR Master Mix consists of a master mix containing the polymerase and proofreading enzyme mixture, dNTPs, and MgCl2. Also provided are control primers, human genomic control DNA, and nuclease-free water. 

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