Report

Sexual Deprivation Increases Ethanol Intake in Drosophila

See allHide authors and affiliations

Science  16 Mar 2012:
Vol. 335, Issue 6074, pp. 1351-1355
DOI: 10.1126/science.1215932

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

This article has corrections. Please see:

Toward Addiction

Addiction can result when substances, such as drugs or alcohol, co-opt the brain's natural reward system. Shohat-Ophir et al. (p. 1351; see the Perspective by Zars) explored this potential in Drosophila by examining the relationship between the natural reward stimulated by mating and the unnatural reward offered by ethanol consumption. Males deprived of mating increased consumption of ethanol, and, when permitted to mate following deprivation, their ethanol consumption decreased. At a mechanistic level, mating increased the neurotransmitter neuropeptide F (NPF), while mate deprivation decreased NPF levels.

  • Present address: Howard Hughes Medical Institute, Janelia Farm Research Center, Ashburn, VA 20174, USA.

View Full Text