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Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode

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Science  16 Mar 2012:
Vol. 335, Issue 6074, pp. 1362-1366
DOI: 10.1126/science.1216937

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A Synaptic Vesicle in Time

Synaptic vesicles move extensively within presynaptic nerve terminals, and their positional features are thought to have an impact on the likelihood and mode of vesicle fusion and transmitter release. Park et al. (p. 1362, published online 16 February) now provide real-time, three-dimensional tracking of individual synaptic vesicles in living nerve terminals. Single synaptic vesicles were identified within hippocampal neurons right up to the moment of exocytosis.

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