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The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

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Science  18 May 2012:
Vol. 336, Issue 6083, pp. 918-922
DOI: 10.1126/science.1215327

Article Information

vol. 336 no. 6083 918-922

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 17, 2011
  • Accepted for publication March 23, 2012
  • .

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Author Information

  1. Simon A. Hawley1,
  2. Morgan D. Fullerton2,
  3. Fiona A. Ross1,
  4. Jonathan D. Schertzer2,
  5. Cyrille Chevtzoff1,
  6. Katherine J. Walker1,
  7. Mark W. Peggie3,
  8. Darya Zibrova3,
  9. Kevin A. Green1,
  10. Kirsty J. Mustard1,
  11. Bruce E. Kemp4,
  12. Kei Sakamoto3,*,
  13. Gregory R. Steinberg2,4,
  14. D. Grahame Hardie1,
  1. 1Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.
  2. 2Divisions of Endocrinology and Metabolism, Department of Medicine, and Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.
  3. 3Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.
  4. 4St. Vincent’s Institute of Medical Research and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic 3065 Australia.
  1. To whom correspondence should be addressed: E-mail: d.g.hardie{at}dundee.ac.uk
  • * Present address: Nestlé Institute of Health Sciences Société Anonyme, Campus École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

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