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Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

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Science  25 May 2012:
Vol. 336, Issue 6084, pp. 1040-1044
DOI: 10.1126/science.1218595

Article Information

vol. 336 no. 6084 1040-1044

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 30, 2011
  • Accepted for publication March 23, 2012
  • .

Author Information

  1. Mohit Jain1,2,3,4,*,
  2. Roland Nilsson1,2,3,5,*,
  3. Sonia Sharma6,
  4. Nikhil Madhusudhan1,2,3,
  5. Toshimori Kitami1,2,3,
  6. Amanda L. Souza1,
  7. Ran Kafri2,
  8. Marc W. Kirschner2,
  9. Clary B. Clish1,
  10. Vamsi K. Mootha1,2,3,
  1. 1Broad Institute, Cambridge, MA 02142, USA.
  2. 2Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Center for Human Genetic Research and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
  4. 4Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  5. 5Unit of Computational Medicine, Department of Medicine, Karolinska Institutet, 17176 Stockholm, Sweden.
  6. 6La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
  1. To whom correspondence should be addressed. E-mail: vamsi{at}hms.harvard.edu
  1. * These authors contributed equally to this work.

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