06 July 2012
Vol 337, Issue 6090

About The Cover

Cover image expansion

COVER Structure of the Wnt signaling molecule (red) in complex with the Frizzled ligand-binding domain (yellow), schematically depicted as connected to the cell surface. A key feature of this structure is the visualization of a lipid group (blue) on Wnt directly engaging Frizzled. The Wnt/Frizzled mode of binding paves the way for the design of Wnt-based therapeutics. See page 59. Image produced by Eric Smith and Chris Garcia